Red blood cells (RBCs) ship oxygen to tissues and in addition contribute to hemostasis and thrombosis via platelet interactions that promote clot formation. In addition, BloodVitals SPO2 device RBC release adenosine 5′-diphosphate (ADP) and extracellular vesicles, which promote procoagulant conditions. It has additionally been observed that prolonged bleeding occasions will be decreased in anemic patients with RBC transfusions, but the physiology was unknown. To achieve a greater understanding of the consequences of RBCs on hemostasis, researchers reconstituted human blood at various hematocrits and perfused it over immobilized collagen in a microfluidic chamber to mimic arterial wall sheer stress after vascular injury. Increasing hematocrit elevated platelet thrombus formation under stream conditions, BloodVitals SPO2 device but RBC membrane integrity was vital for RBCs to promote platelet aggregation. Mice with pancytopenia induced by irradiation formed small platelet-poor clots at vascular harm sites, however clot dimension elevated 3- to 5-fold when mice were transfused with RBCs suggesting that RBCs enhance hemostasis even in the near absence of platelets. Further, results suggest that prime sheer stress trigger RBCs to launch ADP and activate platelets and clot formation in patients with left ventricular help units. Additional studies are needed to higher understand the role of RBCs in hemostasis. Cheryl L. Maier, blood oxygen monitor Wilbur A. Lam
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RBCs Regulate Hemostasis by Platelet Dependent And Independent Mechanisms
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