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This family accommodates just one protein, SET7/9, which mono-methylates histone at H3K4 92 KMT7 was found to methylate, apart from histone, numerous non-histone proteins, including p53, DNA methyltransferase 1 (DNMT1), estrogen receptor alpha (ERα), nuclear issue kappaB (NFκB), and parts of the TATA binding protein (TBP) complicated, TBP-associated elements TAF10 and TAF7 93 The consensus recognition sequence in substrates for SET7-mediated lysine methylation, K/R-S/T-Ok (goal lysine is daring), can be recognized by the H3K4 demethylase KDM1A/LSD1, which is capable of removing the methyl mark on most of those substrates 17 , 94 Due to this fact KMT7/KDM1A has emerged as a traditional mannequin for dynamic lysine methylation of both histone and non-histone proteins. |
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The animals, to Ian Malcolm ‘s shock, continued to thrive on Isla Sorna regardless of the lysine failsafe due to the herbivore's abilities to devour soy and other lysine-wealthy meals. N, amino terminus |
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